hrp0097p1-513 | Growth and Syndromes | ESPE2023

Efficacy of Once-Weekly Treatment for Paediatric Growth Hormone Deficiency: A Systematic Literature Review and Indirect Treatment Comparison

Schaible Kassandra , Huelin Rachel , Loftus Jane , Nijher Monica , Neupane Binod , Cappelleri Joseph , Fahrbach Kyle

Introduction: Paediatric growth hormone deficiency (pGHD) is a rare disorder characterised by inadequate secretion of growth hormone (GH). Daily injections of somatropin, a recombinant human GH, is the standard of care. Once-weekly GH treatments have been recently developed, but no direct comparisons have been published. This study examined the clinical efficacy of the available once-weekly treatments vs. daily treatment for pGHD via a systematic literature re...